{"id":4508,"date":"2016-04-19T12:02:22","date_gmt":"2016-04-19T10:02:22","guid":{"rendered":"http:\/\/www.vandaomeopatici.it\/it\/?p=4508"},"modified":"2020-09-13T11:16:00","modified_gmt":"2020-09-13T09:16:00","slug":"curcumina-malattie-osteoarticolari","status":"publish","type":"post","link":"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/","title":{"rendered":"Curcumina e malattie osteoarticolari"},"content":{"rendered":"

Curcumina e malattie osteoarticolari<\/h1>\n

<\/h1>\n

I dati disponibili derivanti da studi in vitro e in vivo affermano che la Curcumina pu\u00f2 essere un efficace trattamento complementare nelle affezioni cronico degenerative a carico dell\u2019apparato osteoarticolare, tanto negli umani che negli animali da compagnia.<\/p>\n

Essa \u00e8 risultata essere la pi\u00f9 sicura e la pi\u00f9 adatta alternativa nutraceutica ai FANS che sono correntemente impiegati nel trattamento di tali patologie.<\/p>\n

Agisce soprattutto proteggendo i condrociti dagli effetti catabolici dell\u2019IL-1 beta e del TNF-alfa, due citochine proinfiammatorie pleiotropiche che giocano un ruolo chiave nel mediare la degradazione cartilaginea nei disordini osteoarticolari come l\u2019osteoartrite e l\u2019artrite reumatoide.<\/p>\n

A livello cellulare l\u2019IL-1 beta e il TNF-alfa attivano gli enzimi degradanti la matrice (MMP 2, 3 e 9) tramite l\u2019attivazione dell\u2019NFkB, inibiscono l\u2019epressione dei componenti stessi della matrice (proteoglicani), inducono l\u2019apoptosi dei condrociti, aumentano l\u2019espressione del collagene Tipo II, dell\u2019Integrina beta 1 e della Ciclossigenasi 2 (COX 2).<\/p>\n

Pertanto la Curcumina, antagonizzando i cruciali effetti catabolici operati dall\u2019 IL-1 beta e dal TNF-alfa, che sono riconosciuti essere fondamentali nella patogenesi delle infiammazioni cronico degenerative osteoarticolari, potrebbe offrire un nuovo potenziale terapeutico come integratore nutraceutico condroprotettivo nel trattamento di tali problematiche.<\/p>\n

\n

Osteoarthritis Cartilage. 2010 Feb;18(2):141-9.
\nBiological actions of\u00a0curcumin\u00a0on articular chondrocytes.<\/a><\/strong>
\nHenrotin Y,\u00a0Clutterbuck AL,\u00a0Allaway D,\u00a0Lodwig EM,\u00a0Harris P,\u00a0Mathy-Hartert M,\u00a0Shakibaei M,\u00a0Mobasheri A.<\/p>\n

Biochem Pharmacol. 2007 May 1;73(9):1434-45.
\nSuppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis.<\/a><\/strong>
\nShakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A.<\/p>\n

Ann Anat. 2005 Nov;187(5-6):487-97.
\nCurcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study.<\/a><\/strong>
\nShakibaei M, Schulze-Tanzil G, John T, Mobasheri A.<\/p>\n

Ann N Y Acad Sci. 2004 Dec;1030:578-86.
\nEffects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.<\/a><\/strong>
\nSchulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M.<\/p>\n

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Curcumina e malattie osteoarticolari I dati disponibili derivanti da studi in vitro e in vivo affermano che la Curcumina pu\u00f2 essere un efficace trattamento complementare nelle affezioni cronico degenerative a carico dell\u2019apparato osteoarticolare, tanto negli umani che negli animali da compagnia. Essa \u00e8 risultata essere la pi\u00f9 sicura e la pi\u00f9 adatta alternativa nutraceutica ai […]<\/p>\n","protected":false},"author":1,"featured_media":4851,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[415,407,416],"tags":[414,413],"class_list":{"0":"post-4508","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-integratore-curcuma-omega3","8":"category-omeopatia","9":"category-pufacur-integratore-alimentare-curcuma-omega3","10":"tag-curcuma","11":"tag-pnei-psico-neuro-endocrino-immunologia"},"yoast_head":"\nCurcumina e malattie osteoarticolari - Vanda Integrative Medicine<\/title>\n<meta name=\"description\" content=\"la Curcumina pu\u00f2 essere un efficace trattamento complementare nelle affezioni cronico degenerative a carico dell\u2019apparato osteoarticolare\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Curcumina e malattie osteoarticolari\" \/>\n<meta property=\"og:description\" content=\"la Curcumina pu\u00f2 essere un efficace trattamento complementare nelle affezioni cronico degenerative a carico dell\u2019apparato osteoarticolare\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/\" \/>\n<meta property=\"og:site_name\" content=\"Vanda Integrative Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/vandaomeopatici\" \/>\n<meta property=\"article:published_time\" content=\"2016-04-19T10:02:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-13T09:16:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.vandaomeopatici.it\/it\/wp-content\/uploads\/2016\/04\/pufacur-curcuma-malattie-osteoarticolari.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"960\" \/>\n\t<meta property=\"og:image:height\" content=\"640\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Laboratorio Vanda\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@VandaOmeopatici\" \/>\n<meta name=\"twitter:site\" content=\"@VandaOmeopatici\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Laboratorio Vanda\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/\"},\"author\":{\"name\":\"Laboratorio Vanda\",\"@id\":\"https:\/\/www.vandaomeopatici.it\/it\/#\/schema\/person\/0d450801a797ff386b3694196e19de69\"},\"headline\":\"Curcumina e malattie osteoarticolari\",\"datePublished\":\"2016-04-19T10:02:22+00:00\",\"dateModified\":\"2020-09-13T09:16:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/\"},\"wordCount\":355,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.vandaomeopatici.it\/it\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.vandaomeopatici.it\/it\/wp-content\/uploads\/2016\/04\/pufacur-curcuma-malattie-osteoarticolari.jpg\",\"keywords\":[\"curcuma\",\"Pnei\"],\"articleSection\":[\"Integratore Curcuma e Omega 3\",\"Omeopatia\",\"Pufacur Integratore Alimentare\"],\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/\",\"url\":\"https:\/\/www.vandaomeopatici.it\/it\/curcumina-malattie-osteoarticolari\/\",\"name\":\"Curcumina e malattie osteoarticolari - 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